Led by Mirja Effing and Cajus Wacker, the book draws on the collective clinical insights of physicians within the KEM medical network, who systematically evaluated potential causes and therapeutic outcomes in affected patients. Dr. Kurt E. Müller — a recognized pioneer of environmental medicine in Germany and Europe — contributed as scientific advisor, ensuring the work combines clinical experience with up-to-date scientific understanding.
With sections on medical history, laboratory diagnostics, therapeutic approaches, underlying pathomechanisms, billing information, and a glossary of therapeutic agents, this handbook serves as an essential, practice-oriented resource for healthcare professionals.
Symptoms treated with this new knowledge:
- ME/CFS is often described as “the illness that follows”—a severe and long-lasting condition that can develop after an acute infection and affect anyone. This book explains the disorder in a clear and understandable way. It provides essential knowledge for conversations with doctors and offers practical guidance for navigating social issues such as disability assessment, rehabilitation, and disability benefits. It serves as a concise and accessible introduction for patients, families, and healthcare professionals, based on the current state of scientific research.
- Mast Cell Activation Syndrome (MCAS) and Mast Cell Activation Disorders (MAS) are conditions in which mast cells in the body release mediators in an exaggerated or dysregulated way. This can lead to a wide range of symptoms affecting multiple organ systems, making the disorders difficult to recognize and diagnose.
- Fatigue
- Neurological symptoms (including brain fog, sleep disorders, depression, dizziness, dementia)
- Cardiovascular symptoms (e.g., arrhythmia, myocarditis, heart failure)
- Orthostatic intolerance and POTS (postural orthostatic tachycardia syndrome)
- Gastroenterological symptoms (e.g., leaky gut, constipation, candida)
- Circulatory disorders (e.g., endotheliitis, microthrombi)
Reference:
“Highly competent, clearly structured, scientifically sound, and based on real experience, this guide is a true compass and ray of hope in the jungle of symptoms associated with long COVID and post-vaccination syndrome. It has become an absolute must in my daily practice! Thank you!”
Dr. Frauke Hellweg
Book: Flexicover, 115x185 mm, 176 pages, black and white.
Publisher: Sound of Truth Publishing UG.
Language: German.
Publication date: November 2025, 1st edition.
Publisher: Sound of Truth Publishing UG.
Language: German.
Publication date: November 2025, 1st edition.
FAQ
1. What is the difference between Long COVID, Post-COVID, and Post-Vac syndrome? ▸
Long COVID refers to symptoms that persist or newly emerge weeks after acute COVID-19 infection, typically beyond four weeks. Post-COVID syndrome usually describes a longer phase (often defined as symptoms lasting 12+ weeks after infection). Post-Vac syndrome is used informally for prolonged symptoms emerging after vaccination, but it lacks a standardized medical definition and is not the same as routine short-term vaccine side effects.
2. Can fatigue, brain fog, or dizziness really come from Long COVID? ▸
Yes — many people with Long COVID report persistent fatigue, cognitive difficulties (“brain fog”), and dizziness. Research suggests these may be linked to ongoing inflammation, autonomic nervous system disturbances, and changes in energy metabolism, although mechanisms are still being studied.
3. What does “Spikeopathy” mean and how is it related to symptoms? ▸
“Spikeopathy” is a term used in some literature to describe conditions thought to be associated with effects of the SARS-CoV-2 spike protein on tissues. In the context of post-infection or post-vaccination conditions, it refers to hypotheses about how spike proteins might interact with cells or immune pathways; this concept is discussed in clinical guides but remains a topic of ongoing scientific investigation, not a universally recognized diagnosis.
4. What is Post-Vac syndrome and how is it different from normal vaccine side effects? ▸
Post-Vac syndrome refers to prolonged or atypical symptoms reported after vaccination that last beyond the usual few days of expected side effects. Normal vaccine side effects (e.g., soreness, mild fever) are usually short-lived and self-limiting; in contrast, Post-Vac syndrome is a term used by some patients and clinicians for longer-lasting issues, though it lacks a standardized clinical definition.
5. What role do immunological dysregulations (immune problems) play in persistent post-infection symptoms? ▸
Immunological dysregulation may contribute to persistent symptoms after infection by sustaining low-grade inflammation, altering immune signaling, or triggering autoimmune-like responses. These immune system changes are under active research, and they can help explain why some individuals experience lingering multi-system complaints after COVID.
6. Are there scientific books on spikeopathy? ▸
There are specialist medical and clinical guides that discuss the concept of spike protein-related mechanisms within the broader context of post-COVID and post-vaccination conditions. One example are the guidelines: Leitfaden Diagnostik & Therapie – Post-COVID, Post-Vac-Syndrom & Spikeopathie by Mirja Effing and Cajus Wacker, which provides evidence-oriented discussion aimed at clinicians and informed readers.
Guide to Diagnosis and Treatment of Post-COVID and Post-Vaccine-Syndrome, Spikeopathy